Prof. Ione Schneider1, Ms Lais Fontanela1, MsC Vanessa Pereira Corrêa Rampinelli1, Prof. Cesar Oliveira2, Prof. Danielle Vieira1
1Federal University Of Santa Catarina, Araranguá, Brazil, 2University College London, London, United Kingdom
Biography:
Professor in the Physiotherapy Program and the Graduate Programs in Rehabilitation Sciences and Public Health at the Federal University of Santa Catarina (UFSC). Holds a Bachelor’s degree in Physiotherapy from the State University of Santa Catarina and specialized in Cardiopulmonary Physiotherapy, Oncology and Palliative Care Physiotherapy, and Neurosciences. Obtained a Master’s degree and a Ph.D. in Public Health from UFSC. Completed postdoctoral research in the Graduate Program in Public Health at UFSC and at University College London. Coordinator of the Epidemiology Research Laboratory at UFSC.
Abstract:
Background:
Distinct pulmonary function (PF) trajectories arise throughout life impacting health outcomes. This study aims to identify PF trajectories in older adults and examine their association with all-cause mortality.
Methods:
A cohort study was conducted with 2,427 participants aged ≥50 years from the English Longitudinal Study of Ageing (ELSA). PF trajectories were derived from z-scores of forced expiratory volume in one second (FEV1) measured at waves 2, 4, and 6. Death records were obtained from the Office for National Statistics. Participants without mortality information were censored at their last survey participation (wave 7, 8, or 9), with a maximum follow-up of 60 months. A group-based trajectory model was used to identify PF trajectories. To estimate mortality risk, crude and adjusted semi-proportional Cox hazard models were performed.
Results:
Most participants were female (54.68%) and aged 50–69 years (49.38%). Three pulmonary function (PF) trajectories were identified: low (z-scores between -2.5 and -1.5; n = 400, 16.48%), average (z-scores between -1 and 0; n = 1,380, 56.86%), and high (z-scores between 0 and 1; n = 647, 26.66%). During the follow-up, 196 deaths were recorded.). However, in the adjusted model, the increased mortality risk in the low PF trajectory compared to the high PF trajectory was significant only among women (2.25, 95% CI: 1.13–4.47).
Conclusion:
This study identified three PF trajectories and their association with mortality, particularly in women, emphasizing the need to monitor PF in aging populations.
Acknowledgment: IS thanks the National Council for Scientific and Technological Development.